High‐quality relationships,psychological safety,and learning from failures in work organizations

How can organizations support employees to engage in learning from failures? In this paper, we draw on the concept of high‐quality relationships to explore the relational underpinnings of learning from failures in organizations. We focus on relational coordination as a specific manifestation of high‐quality relationships and examine how the relational dimensions of relational coordination—shared goals, shared knowledge, and mutual respect—foster psychological safety and thus enable organizational members to engage in learning from failures. The results of two separate studies support our mediation model where psychological safety mediates the link between high‐quality relationships and learning from failures in organizations. Copyright © 2008 John Wiley & Sons, Ltd.     

Does the financing of extended producer responsibility influence economic growth?

The question of how the financing of Extended Producer Responsibility (EPR) affects the overall performance of the economy is important as products covered by EPR comprise an increasing part of the economy. In this paper, an Overlapping Generations (OLG) model with endogenous growth is applied to the case and a comparison between two financing schemes, an insurance solution and a pay-as-you-go (PAYG) solution, is made with respect to the effect on the level of production, the growth rate, the impact of a productivity shock and the risk exposure. It is found that in the case of a funded solution, both the level of production and the growth rate in production is higher than in the PAYG case, and the short-run effect of productivity shock is bigger. The policy indication is clear: EPR should be attached to a financing scheme if welfare is to be maximised.     

Environmental resource footprinting of drug manufacturing: Effects of scale-up and tablet dosage

The formulation and scale-up of batch processes is one of the major challenges in the development of pharmaceutical dosage forms and at the same time a significant resource demanding process which is generally overlooked in environmental sustainability assessments. First, this paper proposes general trends in the experience curve of cumulative resource consumption of pharmaceutical tablet manufacturing of PREZISTA^® 800 mg through wet granulation (WG) at four consecutive scales in both R&D and manufacturing environments (resp. WG1 = 1 kg/h, WG5 = 5 kg/h, WG30 = 30 kg/h and WG240 = 240 kg/h). Second, the authors aim at evaluating the environmental impact from a life cycle perspective of a daily consumption of PREZISTA^® 2× 400 mg tablets versus the bioequivalent PREZISTA^® 800 mg tablet which was launched to enhance patient compliance. Environmental sustainability assessment was conducted at three different system boundaries, which enables identification, localization and eventually reduction of burdens, in this case natural resource extraction. Exergy Analysis (EA) was used at process level (α) and plant level (β) while a cradle-to-gate Exergetic Life Cycle Assessment (ELCA) was conducted at the overall industrial level (γ) by means of the CEENE method (Cumulative Exergy Extraction from the Natural Environment). Life cycle stages taken into account are Active Pharmaceutical Ingredient (API) production, Drug Product (DP) production and Packaging. At process level (α), the total resource extraction for the manufacturing of one daily dose of PREZISTA^® (800 mg tablet) amounted up to 0.44 MJ_ex at the smallest scale (WG1) while this amount proved to be reduced by 58%, 79% and 83% at WG5, WG30 and WG240 respectively. Expanding the boundaries to the overall industrial level (γ) reveals that the main resource demand is at the production of the Active Pharmaceutical Ingredient (API), excipients, packaging materials and cleaning media used in DP production. At the largest scale (WG240) the use of cleaning media during DP production contributes considerably less to the total resource extraction. Overall, the effect of scale-up and learning on resource consumption during DP production showed to possess a power-law experience curve y = 2.40 * x^−0.57 when shifting from WG1 (smallest lab scale) to WG240 (industrial manufacturing). Tablet dosage (2× 400 mg versus 1× 800 mg) did not significantly affect the absolute environmental burden. However, the relative contribution of resource categories did change due to the different production technology. It could be concluded that in meeting social and economic demands by launching the PREZISTA^® 800 mg tablet, no trade-off in environmental burden occurred. On the long term, future research should strive to take into account R&D processes and all services related to pipeline activities taking place prior to market launch and eventually to allocate impacts to the final product.     

Ventilation rate and copulation in Octopus vulgaris

Typically three events occur when Octopus vulgaris Cuvier mates. The male inserts its hectocotylus into the mantle cavity of the female; the hectocotylus and the bodies of the male and female become quiescent; and the female increases its ventilation rate about 2.5 times, on the average, above its precopulatory base rate. It is hypothesized that the increased ventilation rate of the female provides the stimulus to the male to transfer its spermatophore to the oviduct. Since the insertion of the hectocotylus and the female's increased ventilation rate may be dissociated, it is suggested that copulation be defined as the attachment of the hectocotylus to the oviduct. A conditioned ventilation-rate increase in the female was observed with repeated testing. Observation of arching and pumping movements of the male as well as measurements of its ventilation rate before and during copulation indicate that only a few spermatophores are transferred per copulation.     

On a Temporal Investigation of Hurricane Strength and Frequency

Hurricanes originating in the West Atlantic often have devastating consequences on the cities in the US east coast, both monetary and otherwise, and hence pose a source of considerable concern to several authorities. The possibility of a connection between global warming in general and an increased frequency of these strong hurricanes is well researched, but is still actively debated. The present work tries to promote the use of a smoothing statistic termed empirical recurrence rates and to advocate the use of another, termed empirical recurrence rates ratio in a bid to better understand the rich history of these storms on one hand and to make appropriate inferences on the other, so that some light can be shed on the acceptability of conjectures held by renowned climate scientists. The methods introduced are intuitive and simple to implement and should find wide applications in diverse disciplines.

     

Income and Price Elasticities of Bushmeat Demand in Lowland Amerindian Societies

Abstract: Consumption of bushmeat is an important component of household economies in most tropical forested regions of the world and is resulting in unsustainable levels of hunting, even in relatively isolated regions. We conducted standardized surveys of household consumption, income, wealth, and education level among Amerindian societies in Central and South America. Results suggest 1) demand for bushmeat may follow an inverted ∪ pattern with income, 2) consumers, particularly the most well-off, reduce their consumption of bushmeat as the price increases; and 3) a small decrease in the price of meat from domesticated animals is likely to lead to a large decrease in the consumption of fish but not of bushmeat. Policy makers may be able to reduce demand for bushmeat by raising the price of bushmeat, by increasing the direct and opportunity costs of hunting, and by raising household income.